Dissociatives
Ketamine, PCP, DXM, nitrous oxide — substances that produce dissociation through NMDA antagonism.
Latest reporting
The Ketamine Clinic Boom Is About to Meet the Same Federal Prosecutor Who Ended Florida's Pill Mills
A $3.4 billion industry grew from fewer than 100 clinics to more than 1,500 in a decade with almost no dedicated federal rulebook. Two federal fraud indictments and an expiring telehealth waiver suggest that era is ending.
She Emailed a Stranger 'I Think I'm Dying.' He Wrote Back With the Only Help That Existed.
Amy Massey's bladder was failing from years of ketamine use when she emailed a stranger for help. Drug services had nothing to offer her. The peer network she helped build did.
Ketamine Got Rebranded as a Miracle Depression Drug. The Bladder Surgeries Never Left.
Ketamine clinics grew from under 100 to 1,500+ in a decade. Recreational use is rising alongside them, and the DEA's response — emergency-scheduling a little-used analog — is drawing fire from its own harm reduction allies.
Through eight lenses
Science
NMDA receptor antagonism (ketamine, PCP, DXM), nitrous as N2O NMDA + opioid.
The Ketamine Clinic Boom Is About to Meet the Same Federal Prosecutor Who Ended Florida's Pill Mills
Jul 25The Clinic on Every Corner: Ketamine Is Treating Depression and Creating New Addictions Simultaneously
Jun 25France Just Approved IV Ketamine for Suicidal Crisis. The US Has an Excuse, Not an Answer.
Jun 16
Biology
Dissociation at moderate doses; K-hole at higher; ketamine bladder toxicity with chronic recreational use; B12 deficiency and neuropathy from nitrous.
Psychology
Dissociative experience; emerging ketamine use disorder pattern; the therapy/recreation confusion.
Policy
Ketamine Schedule III; esketamine (Spravato) FDA-approved for TRD; nitrous legal and lightly regulated; PCP Schedule II.
The Ketamine Clinic Boom Is About to Meet the Same Federal Prosecutor Who Ended Florida's Pill Mills
Jul 25Three Different Clocks Are Running Out on Mail-Order Ketamine, and Only One of Them Is About Safety
Jul 3France Just Approved IV Ketamine for Suicidal Crisis. The US Has an Excuse, Not an Answer.
Jun 16
Trends
Ketamine clinics exploding; WhipIt+ canister culture; DXM abuse among adolescents declining.
Ketamine Got Rebranded as a Miracle Depression Drug. The Bladder Surgeries Never Left.
Jul 5Ketamine's Regulatory Reckoning: Clinic Oversight, DEA Enforcement, and the Line Between Medicine and Misuse
May 26Dissociatives in 2026: Texas Is About to Reshape Ketamine Care — and Other States Are Watching
May 21
Treatment
Ketamine use disorder — sparse evidence, harm-reduction-heavy approach.
Harm Reduction
Nitrous B12 supplementation, ketamine urinary-tract monitoring, don't mix dissociatives with depressants.