Dissociatives
Ketamine, PCP, DXM, nitrous oxide — substances that produce dissociation through NMDA antagonism.
Latest reporting
Ketamine Is Becoming Medicine and Contraband at the Same Time
Ketamine is being rehabilitated as first-line psychiatric medicine and cracked down on as a diverted street drug at the same time — here's what the 2026 data on Spravato, chronic pain, DEA scheduling, and the UK youth crisis actually shows.
Ketamine Isn't Just Rewiring Your Mood. It's Quietly Eating Your Bladder From the Inside.
The biology behind ketamine-associated bladder dysfunction — a real, dose-dependent injury pattern showing up in both party users and, increasingly, patients getting frequent clinic infusions for depression.
The Drug Being Fast-Tracked as a Depression Cure Is Quietly Costing Some People Their Bladders — and No One in the System Saw It Coming
As the UK debates ketamine's legal classification, Amy Massey's near-bladder-removal and the peer network that intervened where clinics couldn't show where the real harm reduction is happening.
Through eight lenses
Science
NMDA receptor antagonism (ketamine, PCP, DXM), nitrous as N2O NMDA + opioid.
Biology
Dissociation at moderate doses; K-hole at higher; ketamine bladder toxicity with chronic recreational use; B12 deficiency and neuropathy from nitrous.
Ketamine Isn't Just Rewiring Your Mood. It's Quietly Eating Your Bladder From the Inside.
Aug 4The Clinic on Every Corner: Ketamine Is Treating Depression and Creating New Addictions Simultaneously
Jun 25Substance Spotlight: dissociatives — ketamine clinics, Spravato, and the regulatory gray zone
May 21
Psychology
Dissociative experience; emerging ketamine use disorder pattern; the therapy/recreation confusion.
Policy
Ketamine Schedule III; esketamine (Spravato) FDA-approved for TRD; nitrous legal and lightly regulated; PCP Schedule II.
The Ketamine Clinic Boom Is About to Meet the Same Federal Prosecutor Who Ended Florida's Pill Mills
Jul 25Three Different Clocks Are Running Out on Mail-Order Ketamine, and Only One of Them Is About Safety
Jul 3France Just Approved IV Ketamine for Suicidal Crisis. The US Has an Excuse, Not an Answer.
Jun 16
Trends
Ketamine clinics exploding; WhipIt+ canister culture; DXM abuse among adolescents declining.
Treatment
Ketamine use disorder — sparse evidence, harm-reduction-heavy approach.
Harm Reduction
Nitrous B12 supplementation, ketamine urinary-tract monitoring, don't mix dissociatives with depressants.