Every substance,
in depth.
Living reference pages on opioids, stimulants, alcohol, and every major drug class Rize covers. Each one examined the same way, so you can understand it start to finish.
Eight lenses:ScienceBiologyPsychologyPolicyTrendsSocial & CulturalTreatmentHarm Reduction
Novel & Emerging Psychoactives
Xylazine, medetomidine, kratom, tianeptine, nitazenes, designer benzodiazepines, research chemicals.
Inhalants
Volatile solvents, aerosols, gases, and alkyl nitrites (poppers). The most overlooked substance class in the field.
Nicotine & Tobacco
Combustible tobacco, vaping, smokeless products, and pouches. Still the deadliest legal drug.
Psychedelics & Empathogens
Psilocybin, LSD, MDMA, DMT/ayahuasca, mescaline, ibogaine, 5-MeO-DMT — substances that produce profound altered states.
Dissociatives
Ketamine, PCP, DXM, nitrous oxide — substances that produce dissociation through NMDA antagonism.
Cannabinoids
Cannabis, synthetic cannabinoids (K2/Spice), high-potency concentrates, and unregulated hemp-derived compounds (HHC, Δ-8).
Depressants (non-opioid)
Benzodiazepines, Z-drugs, barbiturates, GHB/GBL, and muscle relaxants — substances that suppress CNS activity.
Alcohol
The most widely used psychoactive substance in America. Associated with more death and disability nationally than all illicit drugs combined.
Stimulants
Cocaine, methamphetamine, prescription amphetamines, MDMA, and cathinones — substances that elevate dopamine and norepinephrine.
Opioids
Natural and synthetic substances acting on opioid receptors, ranging from prescription analgesics to fentanyl analogs.