Cannabinoids
Cannabis, synthetic cannabinoids (K2/Spice), high-potency concentrates, and unregulated hemp-derived compounds (HHC, Δ-8).
Latest reporting
More Americans Now Smoke Weed Every Day Than Drink Every Day. That's Not the Same as a Win.
2025 NSDUH data shows 21.4 million Americans use cannabis daily or near-daily, more than daily drinkers or daily cigarette smokers, for the first time on record.
The Cannabis Rescheduling Hearing Ended. Only One Side Got to Argue.
DEA's rescheduling hearing on moving marijuana to Schedule III concluded July 15, 2026 without a promised livestream; only formal opponents were credentialed as hearing parties. Post-hearing briefs are due August 17.
A Major New Review Found Cannabis Doesn't Curb Cocaine Cravings — It Intensifies Them
A Lancet Psychiatry meta-analysis of 54 trials found cannabinoids help cannabis withdrawal and insomnia but paradoxically increase cocaine cravings, with 44% of trials rated high risk of bias.
Through eight lenses
Science
CB1/CB2 receptor system, THC partial agonist, CBD complex pharmacology, synthetic cannabinoids as full agonists.
Biology
Acute cognitive effects, cardiovascular risk underappreciated, cannabinoid hyperemesis syndrome, dose-response with potency.
Psychology
Cannabis Use Disorder is real (~9% lifetime risk among users, higher w/ daily use), psychosis risk in predisposed individuals with high-potency concentrates.
Your Brain Chemistry May Decide Whether Cannabis Triggers Psychosis. A New Scan Shows How.
Jul 12The Government Is Fighting a Drug-Testing Company in Court Over Whether Weed Is Still a Schedule I Drug
Jul 4The association between cannabis and depression: an updated Systematic Review and Meta-analysis
Jun 15
Policy
Federal schedule I, state-by-state patchwork, 2018 Farm Bill loophole birthing Delta-8/HHC/THC-O.
Trends
Potency has tripled since 2000; daily-use rates rising; vaping concentrates among youth.
Treatment
No FDA-approved meds; CBT, MET, contingency management.
Harm Reduction
Start low/go slow, avoid mixing, be cautious with edibles (delayed onset → redosing), synthetic cannabinoid (K2) toxicity is qualitatively different and severe.